brain-wide networks

The Macé lab addresses how brain-wide networks interact to produce a particular behavior. We use functional ultrasound imaging, a technique we pioneered, to follow neuronal activity in the whole mouse brain. We combine this technique with targeted genetic circuit manipulations and electrophysiological measurements. One goal is to better understand how cognitive processes, such as behavioral switching, arise in the brain across multiple scales and uncover dysfunctions of these networks in psychiatric disorders. Our lab also studies visual processing and develops innovative optogenetic strategies against blindness to restore visual perception and visuomotor function.